Nanobios Lab

I am working as a DBT Women Scientist in the field of Cancer Nanotechnology. My areas of research interest are Nanomedicine as Controlled and Targeted Drug or Gene Delivery, Biomaterials-Intracellular Interactions, Stem Cells and Regenerative Medicine. Cancer Chemoprevention, Anticancer Drugs and its Molecular Mechanisms, and Pre-Clinical Pharmacology. Clinical cancer translational studies is her prime goal.

Significant Publications:

• Poojari, R., Mohanty, B., Kadwad, V., Suryawanshi, D., Chaudhari, P., Khade, B., Srivastava, R., Gupta, S., Panda, D. (2022). Combinatorial Cetuximab targeted polymeric nanocomplexes reduce PRC1 level and abrogate growth of metastatic Hepatocellular Carcinoma in vivo with efficient radionuclide uptake. Nanomedicine: Nanotechnology, Biology, and Medicine, 41, 102529.

• Poojari, R., Sawant, A., Kini, S., Srivastava, R. and Panda, D. (2020). Antihepatoma activity of multifunctional polymeric nanoparticles via inhibition of microtubules and tyrosine kinases. Nanomedicine (Lond)., 15: 381-396.

• Poojari, R., Kini, S., Srivastava, R. and Panda, D. (2016). Intracellular interactions of electrostatically mediated layer-by-layer assembled polyelectrolytes based sorafenib nanoparticles in oral cancer cells. Colloids and Surfaces B: Biointerfaces, 143, 131–138.

• Poojari, R., Srivastava, R. and Panda, D. (2016).  Microtubule targeted therapeutics loaded polymeric assembled nanospheres for potentiation of antineoplastic activity. Faraday Discussions, 186, 45 – 59.

• Poojari, R., Kini, S., Srivastava, R. and Panda, D. (2015). A chimeric cetuximab-functionalized corona as a potent delivery system for microtubule-destabilizing nanocomplexes to hepatocellular carcinoma cells: A focus on EGFR and tubulin intracellular dynamics. ACS Molecular Pharmaceutics, 12, 3908 – 3923.

 

Patents:

•   R. Poojari, D. Panda, R. Srivastava, Drug delivery system. US Patent Granted (US 10,888,551 B2, 2021)

• R. Poojari, D. Panda, R. Srivastava, Targeted polymeric nano-complexes as drug delivery system. US Patent File Application (15/276,810, 2016)

• R. Poojari, D. Panda, R. Srivastava, Drug delivery system. Indian Patent Granted (315542, 2019)

• R. Poojari, D. Panda, R. Srivastava, Targeted polymeric nano-complexes as drug delivery system. Indian Patent Granted (344742, 2020)

• R. Poojari, D. Panda, R. Srivastava, Multifunctional polymeric nanocarrier. Indian Patent Granted (317866, 2019)

• R. Srivastava, D. Chauhan, R. Poojari, A. Rengan, A. De, A. Bukhari, A. Shanavas. TPGS comprised gold coated Poly-(lactic-co-glycolic acid) nanostructures and a process for its preparation. Indian Patent Granted (354678, 2020)

 

Conferences and Abstracts:

• Poojari, R. Srivastava, R., Panda, D. Molecular intersection of a 3-in-1 nanomedicine targeting microtubules, ERK tyrosine kinases with profound nuclear modulations, and quantum imaging for hepatocellular carcinoma therapy. Held at Walter E. Washington Convention Center, USA. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Research 2017; 77 (13 Suppl): Abstract nr 5142. doi:10.1158/1538-7445.AM2017-5142 (Abstract published)

• Poojari, R., Srivastava, R. and Panda, D. (January, 2016). Microtubule targeted therapeutics loaded polymeric assembled nanospheres for potentiation of antineoplastic activity. Nanoparticle Assembly From Fundamentals to Applications: Faraday Discussions, by Royal Society of Chemistry (RSC) held at Mumbai. (Oral presentation)

• Poojari, R., Srivastava, R. and Panda, D. (February, 2016). Smart nanomaterials with microtubule binding drug targets against liver cancer. Tata Memorial Centre Platinum Jubilee, A Conference of New Ideas in Cancer – Challenging Dogmas, held at National Centre for Performing Arts (NCPA), Mumbai. Abstract in European Journal of Cancer 54, suppl.1 (2016), S19. doi: 10.1016/S0959-8049(16)31953-0 (Poster presentation, Abstract published)